Oxalate Oxidase for In Situ H <sub>2</sub> O <sub>2</sub> ‐Generation in Unspecific Peroxygenase‐Catalysed Drug Oxyfunctionalisations**
نویسندگان
چکیده
H2O2-driven enzymes are of great interest for industrial biotransformations. Herein, we show the first time that oxalate oxidase (OXO) is an efficient in situ source H2O2 one these biocatalysts, which known as unspecific peroxygenase (UPO). OXO reasonably robust, produces only CO2 a by-product and uses cheap sacrificial electron donor. UPO has significant potential catalyst selective C−H oxyfunctionalisations, confirm herein by testing diverse drug panel using miniaturised high-throughput assays mass spectrometry. 33 out 64 drugs were converted 5 μL-scale reactions with (conversion >70 % 11 drugs). Furthermore, oxidation tolmetin was achieved on 50 mg scale (TONUPO 25 664) 84 yield, further improved via enzyme immobilization. This one-pot approach ensures adequate levels, enabling rapid access to industrially relevant molecules difficult obtain other routes.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2022
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202207831